[Lista-Algas] Online Seminar: “Disentangling the role of regulated cell death in cyanobacteria”
Asociación Argentina Ficología
aaficologia at gmail.com
Mon Apr 4 13:43:38 -03 2022
Compartimos información recibida sobre un interesante Seminario Online.
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fibamdp posted: " Jueves 14 de abril de 2022, 12 horas (GMT-3,
Argentina), 4 p.m. CET Anabella Aguilera Centre for Ecology and Evolution
in Microbial Model Systems (EEMiS). Linnaeus University, Sweden Anabella is
from Argentina and has a B. Sc. "
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Online
Seminar: “Disentangling the role of regulated cell death in cyanobacteria”
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* Jueves 14 de abril de 2022, 12 horas (GMT-3, Argentina), 4 p.m. CET*
*Anabella Aguilera*
Centre for Ecology and Evolution in Microbial Model Systems (EEMiS).
Linnaeus University, Sweden
Anabella is from Argentina and has a B. Sc. in Biology, orientation
Ecology, from Universidad Nacional de La Plata (2011). She did her
posgraduate studies in INBIOTEC and FIBA (Fundación para Investigaciones
Biológicas Aplicadas) in Mar del Plata, under the supervision of Dr
Graciela Salerno, and obtained her PhD degree at the Universidad de Mar del
Plata (2017). As a postdoctoral fellow at the same Center, she began
studying Cell Death by Ferroptosis in Synechocystis together with Dr. María
Victoria Martin, in the Cyanobacteria Group led by Dr. Salerno. For two
years she has been doing postgraduate studies at the Linnaeus University,
Sweden.
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The talks will be ~30min and afterward, there will be time to get in
contact with the speaker and ask questions in the Q&A session.
*Registration link on the website: * Register Here!
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https://www.synmikrobiologie.hhu.de/cyano-online-seminar.html
https://us02web.zoom.us/meeting/register/tZcufuCrrj0jGtCdC36CXlRy7Bto4_N85jus
*About the Seminar*: "In contrast to accidental cell death, regulated cell
death (RCD) is a genetically encoded signaling cascade that culminates in
cell suicide and can be activated as the final step of cell differentiation
or induced upon biotic orabiotic stress. In cyanobacteria, RCD is suggested
to play a key role in developmental processes, such as akinete and
heterocyst differentiation. Also, evidence has accumulated on RCD
mechanisms triggered under unfavorable environmental conditions. However,
our understanding of the underlying mechanisms and molecular machinery
underpinning cell death in cyanobacteria remains largely limited."
In this talk, Anabella will review the recent findings working with the
model cyanobacterium *Synechocystis *PCC 6803 (*Aguilera & Berdun* *et al.,
2022*). In this article, it is described a novel cell death program induced
by heat stress with features resembling eukaryotic ferroptosis.
Cyanobacterial ferroptosis is suppressed by the canonical ferroptosis
inhibitors and by the addition of the antioxidant glutathione and ascorbic
acid. This pathway is also characterized by an early depletion of both
antioxidants and by lipid peroxidation. These results indicate that the
main hallmarks of eukaryotic ferroptosis are conserved in cyanobacteria,
and suggest that ferroptosis might be an ancient cell death program.
Moreover, this work contributes to understandinghow cyanobacteria cope with
environmental stress and activate RCD. Finally, I will present our next
steps aiming to uncover mechanisms of stress response and RCD in
bloom-forming cyanobacteria and assess their importance in bloom dynamics.
*Aguilera A*, Berdun F, Bartoli C, Steelheart C, Alegre M, Bayir H, Yulia
Y, Tyurina YY, Kagan VE, Salerno GL, Pagnussat G, Martin MV (2022).
C-ferroptosis is an iron-dependent form of regulated cell death in
cyanobacteria. Journal of Cell Biology 221: e201911005.
doi:10.1083/jcb.201911005.
*fibamdp
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| April 1, 2022 at 12:22 pm | Categories: Uncategorized
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| URL: https://wp.me/pM5O4-5be
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*Dr. Ricardo Echenique*División Ficología "Dr. Sebastián Alberto Guarrera"
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Argentina
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