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<DIV><B><I><SPAN
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">Just
published<o:p></o:p></SPAN></I></B></DIV>
<DIV class=Section1>
<P class=MsoNormal><B><I><SPAN lang=EN-US
style="FONT-SIZE: 8pt; COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">(Pre-ordered
copies have been mailed).</SPAN></I></B><B><I><SPAN lang=EN-US
style="FONT-SIZE: 8pt; COLOR: #76923c; FONT-FAMILY: 'Times New Roman','serif'"><o:p></o:p></SPAN></I></B></P>
<P class=MsoNormal><B><I><SPAN lang=EN-US
style="FONT-FAMILY: 'Times New Roman','serif'"><o:p> </o:p></SPAN></I></B></P>
<P class=MsoNormal><B><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">Leon, R., A.
Galvan and E. Fernandez (eds.): Transgenic Microalgae as Green Cell Factories.
2007. (Adv. Experim.Medicine and Biology, Volume 616). 29 (2 col.) figs. XVI,
131 p. gr8vo. Hardcover. EUR 113.00<o:p></o:p></SPAN></B></P>
<P class=MsoNormal><SPAN lang=EN-US
style="FONT-FAMILY: 'Times New Roman','serif'"><o:p> </o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">Microalgae have
been largely cultured and commercialized as food and feed additives, and their
potential as source of<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">high-added value
compounds is well known. But, in contrast to the large number of genetically
modified bacteria, yeast<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">and even higher
plants, only a few species of microalgae have been genetically transformed with
efficiency. Initial<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">difficulties in
the expression of foreign genes in microalgae have been progressively overcome,
and powerful molecular<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">tools for their
genetic engineering are now on hand. A considerable collection of promoters and
selectable marker<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">genes and an
increasing number of genomic or cDNA sequences have become available in recent
years. More <o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">work is needed to
transform new species of microalgae, especially those that have commercial
value, so that it would<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">be possible to
increase the productivity of traditional compounds or synthesize novel ones.
Silencing transgenes<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">remains as an
important limitation for stable expression of foreign genes. This problem is not
unique to microalgae<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">since it has also
been observed in plants, animals and fungi. A better understanding of the
mechanisms that control the<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">regulation of
gene expression in eukaryotes is therefore needed. In this book a group of
outstanding researchers working on<o:p></o:p></SPAN></P>
<P class=MsoNormal><SPAN lang=EN-US
style="COLOR: #4f6228; FONT-FAMILY: 'Times New Roman','serif'">different areas
of microalgae biotechnology offer a global vision of the genetic manipulation of
microalgae and their<o:p></o:p></SPAN></P>
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